“By acting as an insulin-sensitizing agent, myo–inositol helps to promote proper utilization of the hormone insulin, which in turn supports proper hormone balance, ovarian function, egg quality and menstrual cycle regularity. Myo–inositol may be especially helpful for women with polycystic ovary syndrome (PCOS).”
So I have started taking myo-inositol and D-chiro inositol as I keep reading many many good things about them helping women with PCOS, that they together can restore regular cycles and bring ovulation back. Here’s hoping! I am only on day 3 of taking them. The only 2 changes I have seen so far is that it improved my mood, I am not irrationally angry all the time, thank goodness. I also haven’t been sleeping as good, but that could easily be from Adeline waking me up at night too.
Here is an excerpt from another blogger and her opinions on it, or you can go to her page to view the entire article here:
What is PCOS?
If you are unacquainted with Polycystic Ovarian Syndrome (PCOS), it is the most common endocrine disorder affecting up to 20% of women of reproductive age. PCOS can occur when there is an imbalance of hormones and a surplus of insulin in the blood. Insulin resistance causes elevated levels of estrogen and androgen (male) hormones. Vice versa, elevated levels of estrogen and androgen hormones cause insulin resistance. High hormone levels lead to high insulin levels and the syndrome feeds itself. This leads to a woman’s body being overloaded with hormones and insulin. In turn, this can lead toirregular menstrual periods, the absence of menstrual periods, hirsutism, painful acne and obesity. PCOS causes women to have increased risk of developing hypertension, dyslipidemia, type 2 diabetes and heart disease. It also causes more than 75% of cases of anovulatory infertility (infertility caused by hormonal imbalance).
I started using inosoitol after diet changes and exercises weren’t enough to cure/put my PCOS into remission. Seeking out advice from fellow PCOS-sufferers who discussed their treatments, I noticed that many kept referencing inositol to treat PCOS.
Metformin vs. Types of Inositol
The reasoning behind treating PCOS with inositol is the same that is behind as using Metformin. The main difference is that inositol occurs naturally in food. Inositol is found naturally in fruits, grains, beans and nuts. Both Metformin and inositol act as a glucose sensitizer, which causes cells to absorb glucose when it is initially released. This prevents the release of more glucose, which is one component continuing the cycle of high blood sugar levels, insulin resistance and high hormone levels associated with PCOS.
In one Google search, I found a wealth of information in numerous studies on treating PCOS with inositol. In one study, one group of women suffering from infertility due to PCOS were given a combination of 4000 mg of myo-inositol (generally referred to as inositol) and 400 mg of folic acid while another group was given metformin. The hypothesis of the study was that women suffering from PCOS had a deficiency in inositol levels and by increasing inositol consumption, issues associated with PCOS would be lessened. By taking inositol with folic acid, one group of the study participants showed lower levels of insulin and 65% had ovulation restored. Of the group who were given, 50% had ovulation restored. Additionally, 18% of women who took inositol were able to get pregnant vs. 11% in the Meformin group.
Other studies conducted giving patients inositol showed results such as:
- an increase in HDL cholesterol (good cholesterol) resulting in weight loss
- decreased insulin, triglycerides, testosterone, and blood pressure levels
- decreased androgen hormone levels
- sudden appearance of menstruation and regular menstruation
I also read about the benefits of taking D-chiro inositol in conjunction with myo-inositol. A study was performed regarding metabolic disorders using myo-inositol and D-chiro inositol as a treatment. Women with PCOS are at risk of developing metabolic disorders due to metabolic, hormonal and ovarian dysfunctions associated with PCOS. Women who took a 40:1 ratio (consistent with the levels found naturally in plasma) of myo-inositol and D-chiro inositol versus myo-inositol alone saw a greater improvement in metabolic functions. The author of the study states:
“The combined administration of MI and DCI in physiological plasma ration (40:1) should be considered as the first line approach in PCOS overweight patients, being able to reduce the metabolic and clinical alteration of PCOS and, therefore, reduce the risk of metabolic syndrome.”
It is interesting to note that myo-inositol and D-chiro inositol are a part of the Vitamin B family. There are also nine different types (or stereoisomers) of Inositol. With the combination of myo-inositol and D-chiro inositol, your body is able to produce all types of inositols that it needs.